The Relationship between Inflammation, Oxidative Stress, Blood Sugar, Blood Lipid, Body Mass Index, Fat Mass, and Body Weight in Patients with Type 2 Diabetes

Approximately 2.5-3% of the world’s population suffers from diabetes. This condition is one of the most serious metabolic disorders, resulting in an increase in inflammatory biomarkers (e.g., interleukin-6, TNF-alpha, and CRP). The aim of this study was to investigate the relationship between oxidative stress, inflammation, blood glucose, lipid level, and anthropometric parameters in patients with type 2 diabetes. This cross-sectional study was performed to compare the relationship between inflammatory factors and type 2 diabetes in 45 male and female subjects (age range=35-65 years). For data analysis, independent sample t-test and linear regression were applied. The mean values of fasting blood sugar (FBS), malondialdehyde (MDA), total cholesterol (TC), and body mass index (BMI) were higher in women, compared to men. However, no significant difference was observed between the two genders in terms of other factors. Also, MDA was not directly correlated with FBS, TC, triglyceride, or anthropometric indices (body weight, BMI, and body fat) after adjusting the sex factor. This study showed that the mean values of BMI, TC, and MDA were higher in diabetic women, compared to their male counterparts. Therefore, diabetic patients should pay particular attention to the management of inflammatory factors to facilitate and accelerate the treatment and prevention of complications due to inflammation.