The effect of Hydroalcoholic Extract of Cornus mas L. Seed on Memory Retention and Some Serum Parameters in Alzheimer Induced Male Mice

Aim: In the present study we examine the effect of C. mass L. seed extract on learning, memory and some serum parameters in alzheimer induced male mice.
Material and 48 male mice weighing 25-30 gram divided into six groups including 1- Saline-Saline, 2-STZ-Saline, 3- STZ- Extract 25 mg/kg, 4- STZ-Extract 50 mg/kg, 5- STZ-Extract 75 mg/kg, 6- Saline- Effective dosages of Extract (50 mg/kg). For inducing Alzheimer's disease i.c.v. injection of Streptozotocine (3 mg/kg) was used and learning as well as memory was evaluated through passive avoidance test model. All groups received C.mas seed extract or saline intraperitoneally for 3­weeks. Then they entered into learning testes. Finally all animals were killed and blood was taken from right ventricle. Level of glucose, Triglyceride, and total cholestrole in serum were measured. Also during treatment period, weights of the mice were measured at beginning of each week. The data were analyzed using unilateral variance analysis and Tukey test or Analysis of variance with repeated measures.
ICV administration of STZ significantly decreased memory (P0.05). Reduction of mice weight was Significant (P It seems that C. mas seed extract improved memory in disorders neuronal damage such as Alzheimer's due to reduction of risk factors in the blood and adjustment of the glucose and fatty acid metabolism.