Relationships of MMP-9 and TIMP-1 proteins with chronic obstructive pulmonary disease risk: A systematic review and meta-analysis
Author(s):
Yangxue Li , Yang Lu , Zhuo Zhao , Junnan Wang , Jianxin Li , Weiming Wang , Shumei Li , Lei Song
Abstract:
Background
We performed this meta-analysis in order to collect all the relevant studies to clarify the correlations of matrix metalloproteinase-9 ( MMP-9) and tissue inhibitor of etalloproteinase-1 ( TIMP-1) with chronic obstructive pulmonary disease ( COPD).Materials And Methods
After a literature search in electronic databases, pertinent case-control studies investigating the correlations of MMP-9 and TIMP-1 protein expressions within a COPD setting were enrolled based on our strict inclusion and exclusion criteria. We used key words such as chronic obstructive pulmonary disease, COPD or COAD or chronic obstructive airway disease and matrix metalloproteinases or MMPs to make a searching strategy in this study. STATA software (version 12.0, Stata Corporation, College Station, TX, USA) was utilized for statistical analysis.Results
A total of 20 studies were enrolled into this meta-analysis including 923 COPD patients and 641 healthy controls. The findings of this meta-analysis revealed that serum expression levels of MMP-9 and TIMP-1 protein in COPD patients were higher than those of healthy controls (MMP-9: SMD = 1.44,95%CI = 0.85 ~ 2.04, P Conclusion
The result of this meta-analysis indicates that elevated levels of MMP-9 and TIMP-1 proteins may be correlated with the pathogenesis of COPD , and the two proteins may represent important biological markers for the early diagnosis of COPD.Keywords:
Language:
English
Published:
Journal of Research in Medical Sciences, Volume:21 Issue: 1, 2016 Jan
Page:
4
https://magiran.com/p1510624
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