Cytotoxicity Effects of Citrus Skin Extract On Cancer Cell Line MCF-7

Nowadays, cancer is knownas the main cause of death throughout the word. In recent decades, medical and molecular advances have not only been able to find the reasons and mechanisms of cancer, but they were more successful in early diagnosis and treatment of it. Citrus skin is the accumulation center of many antioxidant and enzymes. Flavonoids and limonene are among the important compounds in the citrus skin and their vital rolesin prevention and treatment of cancer is under study these days. In this research, after cultivation and reproduction of MCF-7cancer cells line and in order to determine, the effectof cellular cytotoxicity of citrus skin extract, these cells were put in exposure to different doses of etanolic extract and after 72 hours, MTT test was done. Results indicate that the ethanolic extract of Orange skin at concentrations 7.5,10 (p ≤ 0.05)and the ethanolic extract of Limon skin at concentrations 2.5,5 (p ≤ 0.01)decrease cell growth significantly in comparition with the control group. the effectof cellular cytotoxicity grows with an increase in the concentrationof extract and the highest percentage of growth inhibition in extract of Orange skin and Limon skin is related to the concentrations of 7.5 and 5 respectively. Thus citrus skin extract is suggested as an effective material in curing cancer in medical advances.