Evaluation of HER2/neu gene amplification frequency in patients with gastric cancer using MLPA method

Abstract:
Background And Aims
Gastric malignancies have the fourth place among the most prevalent cancers. In many cancers, overexpressing of HER2/neu gene has been observed with a poor prediction. Up to now, there is a little information about the duplication of HER2/neu gene in gastric cancer using MLPA method. The present study aimed to investigate the frequency of mutations resulting from amplification of HER2/neu gene using MLPA technique in the patients with gastric cancer.
Methods
This is a descriptive study which carried out on 60 samples of tissue block obtained from gastric cancer patients with endoscopic and surgical history between 1376-1391 years in Afzalipoor health centers to investigate the deletion and insertion mutations in HER2/neu.
Results
The study population consisted of 73.3% females and 26.7% males with the mean age of 62.71. Overall, the frequency of the amplification of HER2/neu gene in the low and high levels was 10% and 3.3%, respectively.
Conclusion
It seems that, the amplification frequency of HER2/neu gene in men is more than women. However, it is recommended to conduct further studies.
Language:
Persian
Published:
Journal of Torbat Heydariyeh University of Medical Sciences, Volume:2 Issue: 4, 2015
Pages:
38 to 45
https://magiran.com/p1530277  
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