Downregulating the Expression of CHID1 by Chitin Microparticles Mixed Leukocyte Culture

chitin and its derivates microparticles (MPs) have immunomodulatory activities. In this study, we examined the effect of size, purity and acetylation degree of chitin MPs on CHID1- encoding SI-CLP, involved in inflammation- gene expression in mixed leukocyte culture.
Small ( Different concentrations of chitinous MPs hadn’t any cytotoxic effects. In gene expression analysis, small-sized chitin MPs ( Size, purity and acetylation degree of chitin MPs influence their interference in immune cells interactions and it seems small-sized chitin MPs can potentially modulate immune responses through decreasing CHID1 gene expression. Using small-sized chitin MPs may be effective to treat allergies which their treatment strategies rely on modulating the immune responses.