Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy

Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptom's severity, but do not treat the source of degeneration. The use of tissue engineering to treat disc degeneration offers a chance to control the pathological course. New methods are presently being examined and have exposed mixed results. One major way of study has been stem cell injections. We go on to define the course of stem cell-mediated modalities in treatment of degenerative lumbar disc herniation.
Methods & Materials/Patients: Literature search was performed in electronic databases PUBMED and EMBASE by means of Mesh terminologies (Nucleus pulposus, therapeutics, annulus fibrosus, intervertebral disc) and keywords (Degenerative disk disease, Stem Cells, Therapy).
The intervertebral disc organization, developing treatments, mesenchymal stem cells, embryonic stem cells, practice in disc degeneration were some sections that were found in analysis for study review design.
Mesenchymal stem cells (MSCs) have revealed potential in small animal models, nonetheless consequences in greater vertebrates have been varied.