Modified natural cycle frozen-thawed embryo transfer in patients with repeated implantation failure: An observational study

Author(s):

Soheila Arefi , Ahmad Hoseini , Fattaneh Farifteh , Hojjat Zeraati

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

Natural endometrium in Frozen-thawed Embryo Transfer (FET) may have some benefits upon implantation in patients with Repeated Implantation Failure (RIF). It might be due to possible differences between natural and stimulated endometrial growth factors and cytokins secretions.

Objective

The objective of this study was to compare the pregnancy rate of FET on modified natural cycle versus hormone replacement therapy (HRT) cycle endometrium in patients with RIF.

Materials And Methods

In this observational study the pregnancy rate of patients with RIF undergoing day 3 FET in natural cycle endometrium (group 1, n=56), were compared with another group of patients with RIF in whom frozen-thawed day 3 embryos were transferred on HRT cycle (group 2, n=52).

Results

The pregnancy rate in group 1 was 41.07%, compared with the pregnancy rate of group 2; 36.5% (p=0.63). The abortion rate was not significantly different among the groups.

Conclusion

It can be concluded that FET in a modified natural cycle is comparable with HRT cycle in patients with RIF.

Keywords:

Embryo transfer , Hormone replacement therapy , Embryo implantation

Language:
English
Published:
International Journal of Reproductive BioMedicine, Volume:14 Issue: 7, Jul 2016
Pages:
465 to 470
https://magiran.com/p1558383  
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