Association of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Infertile Men With Varicocele
Author(s):
Abstract:
Background
Varicocele is one of the most common reasons for male infertility and could impair spermatogenesis through mechanisms that are not well known. Recently, oxidative stress has been introduced as a major reason for male infertility caused by varicocele.Objectives
In the current study, we aimed to assess the TAC (total antioxidant capacity) and MDA (malondialdehyde) as stress oxidative markers in infertile men with varicocele and fertile men, and moreover, their correlation with sperm parameters.Patients and
Methods
This case control study was performed on 43 infertile men with varicocele and 46 men with proven fertility. The ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods were used for seminal plasma TAC and MDA assay, respectively.Results
Lower TAC levels (1.7 ± 0.2 vs. 1.3 ± 0.4 mmol/L, P = 0.0004) and higher MDA levels (2.5 ± 1.1 vs. 5.8 ± 1.9 mmol/L, P Conclusions
Our findings indicated that oxidative stress could play an essential role in male infertility caused by varicocele and may impair spermatogenesis leading to infertility.Keywords:
Language:
English
Published:
Avicenna Journal of Medical Biochemistry, Volume:4 Issue: 1, Winter and Spring 2016
Page:
9
magiran.com/p1566681
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!