Evaluation of Contraceptive Effects of Trimetoprim and 2,4-Diamino-5(3,4-Dichlorophenyl 6- Isopropyloxymethyl Pyrimidine in Male Rats

With the problems resulting from the rapid trend of population growth, the development of procedures capable of decreasing the population growth rate, to inhibit and stagnate this condition is a necessity.
It is obvios that without the contribution and sense of responsibility of men, population control programs and family planning will be unsuccessful. In the present study, attempts have been made to evaluate a newly synthesized analogue of diamino prymidines compounds with the chemical name of 2,4­diamono-5(3,4-dichlorophenyl)-6-isoproppyloxymethyl pyrimidine, (IPO) and trimethoprim (TRI) on male rats.
This study indicates that the compound without any toxic effects, important side effects or serum testosteron changes decreases the fertillity of rats. Also IPO significantly decreases the sperm motility (SM), percent of viable sperm, daily sperm production (DEP) and epidimal sperm reserve (ESR) but TRI decreases the SM and ESR.