Investigation of Zinc Oxide NanoparticlesDeposition Values in Lung of Female Mice of NMRI Variant

Nanotechnology is a term which refers to all advanced technologies of Nano scale. By Nano scale, a dimension of 1-100 nanometers is presumed. Nano zinc oxide is one of the most important nanomaterials which is widely used in business and industry and this has caused some concerts regarding its effect on the environment and human health. There are not many studies of harms of these materials to the body. The present study was done to define the role of zinc oxide nanoparticles and its deposition values in lung. Syrian female mice of NMRI variant were divided into three groups of 10 each: control, 1000 ppm/kg zinc oxide nanoparticles and 2000 ppm/kg zinc oxide nanoparticles treated groups. During a period of 10 days, different doses of zinc oxide nanoparticles (i.e. 1000 and 2000 ppm/kg) were given to treated groups by inhalation, the control group received distilled water by inhalation. Then the mice were dissected and lung was prepared for investigation of zinc oxide nanoparticles deposition by Atomic Absorption Spectrometer. Statistical analysis showed that zinc oxide nanoparticles had significant difference in tissue of the lung which had received doses 1000 and 2000 ppm/kg compared with control group. Consumption of zinc oxide nanoparticles in doses of 1000 and 2000 ppm/kg, deposition of this material significantly increased in lung.