Comparative effect of Flaxseed and Evening primrose oil with vitamin E on severity of Cyclic Mastalgia in women

Flaxseed, Evening Primrose Oil and Vitamin E are the first line treatment of Cyclic Mastalgia, but there is no evidence which reported that the impact of which one is more. So, this study was performed with aim to compare the effect of Flaxseed and Evening Primrose Oil with Vitamin E on the severity of Cyclic Mastalgia in women.
This clinical trial study was performed on 90 patient with Cyclic Mastalgia referred to gynecology clinic of Mashhad Ghaem hospital or the students living in dormitories of Mashhad University of Medical Sciences in 2015. Patients were randomly divided in to three 30 cases groups including Flaxseed group (30 mg daily powder of Flaxseed), Evening Primrose Oil capsule (2 1000mg capsules, daily) and Vitamin E (1 capsule of 400 IU, daily) for two menstrual period. The severity of mastalgia was measured through … at the baseline and end of every two interventional period. Data was analyzed by SPSS software (version 16) and Chi-square, Fridman, Fisher Exact, and ANOVA.
Median of the severity of mastalgia decreased in all three groups of Flaxseed, Evening Primrose Oil and Vitamin E after the intervention. But, three groups were not significantly different in the median of mastalgia before (P=0.779), one month (P=0.380) and two months after the intervention (P=0.764).
Use of Flaxseed, Evening Primrose Oil or Vitamin E lead to reduction in the severity of mastalgia and this reduction in all three groups is the same.