Investigation of Deposition Amount of Zinc Oxide Nanoparticles with Various Doses in Spleen of Female Mice

Due to the increasing production of ZnO nanoparticles and their useful applications in biological systems, fewer studies have been performed about the side effects of these substances on the organism's body. To this end, in this study, we have investigated the deposition amount of zinc oxide nanoparticles on spleen of Syrian female NMRI mice. In this experimental study, 20 heads of female NMRI mice have been studied in the experimental and control groups. ZnO nanoparticles at concentrations of 100 and 300 mg per kg fed in the drinking water for 28 days, and after 28 days the mice were sacrificed, spleen tissue was removed and solved in the acid, and then the amount of deposited zinc oxide in the tissues was measured by atomic absorption spectrophotometry. According to the obtained results, it is observed that there are significant differences between the consumer groups (of ZnO nanoparticles) and control group. Deposition of Zinc oxide nanoparticles which was studied in the drinking water for 28 days in the mentioned experimental groups has had significant effects on the spleen.