Study of Effect of Aerobic Exercise in Particulate Air Pollution TLR4 and IL-1β Genes Expression in Male Wistar Rat's Heart Tissue

Epidemiologic studies have linked exposure to fine Particulate matter air Pollution to broad cause-of-death mortality. In fact, there is no doubt that Regular Aerobic Exercise promotes a range of Physiological changes that Correlate with decreased Morbidity. However, the Effects of long-term Aerobic exercise on the heart Response to PM10 have not been investigated. The present study Evaluated the effect of aerobic Exercise on the heart Inflammatory status of rat Exposed to PM10 Carbon black. In this Research twenty-four adult male Wistar rats (Age: 8 weeks & Weight: 279.29±26.97 g) were divided to 4 groups: A: control (without exposure PM10 and aerobic exercise; n=6), B: aerobic Exercise (five times per week for 4 weeks; n=6), C: exposure to PM10 carbon black (5 mg/m3; per rat; n=6), D: and aerobic Exercise Concomitantly with Exposure to PM10 carbon black (n=6). The gene Expression of TLR4 and IL-1β were Analyzed in heart tissue by Real-Time PCR. In order to determine the significant Differences between groups, two-way ANOVA and LSD post hoc were used. It was found that aerobic Exercise inhibited the PM10 -induced increase in the gene expression of IL-1β. But compared with control group, gene Expression of IL-1β Significantly increased only in C group (P=0.046). We Conclude that four-week Exposure to PM10 carbon black Significantly increase IL-1β in Heart tissue and this situation did not worsen by Aerobic Exercise. Our Results indicate a need for human studies that evaluate the heart responses to aerobic Exercise Chronically performed in Polluted areas.