Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice
Author(s):
Abstract:
Background
Exendin-4 is a similar peptide to GLP-1 and can interfere with various receptors of GLP-1. Bisphenol A (BPA), as an endocrine disruptor chemical, is used in a wide range of plastic products..Objectives
The aim of this study was to clarify several exendin-4 aspects in treatment of metabolic disorders..Methods
In in vivo condition, the BPA (100 µg/kg) and exendin-4 (4 nmol/kg/d) were administered for 20 days in four different groups, and blood glucose, insulin, lipid profile, adipocyte hormones and oxidative stress markers were examined..Results
The results indicate that co-administration of exendin-4 and BPA modified hyperglycemia and hyperlipidemia induced by BPA. Bisphenol A reduced antioxidant level, whereas exendin-4 improved these effects..Conclusions
The findings of these studies suggest that the use of exendin-4 is useful in hyperglycemia, hyperlipidemia and metabolic disorders, induced by BPA..Keywords:
Bisphenol A , Exendin , 4 , Leptin , Adiponectin , Oxidative Stress , Lipid Profile
Language:
English
Published:
Jentashapir Journal of Cellular and Molecular Biology, Volume:7 Issue: 5, Oct 2016
Page:
6
https://magiran.com/p1620902
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