The Role of CB1 Receptors on Central Food Intake Regulation in ad libitumfedLayer-type Chicken

Inroduction & Mechanisms that regulate appetite are different among animals. Also, nutritional status (food deprived or satisfied) has key role on appetite regulation. Endocannabinoids have crucial role on central food intake regulation in birds but its role has not been studied in layer-type chicken fed ad libitumThus, in this study 3 experiments designed to evaluate effects of intracerebroventricular (ICV) administration of 2-AG (2- Arachidonoylglycerol, selective CB1 receptors agonist), SR141716A (selective CB1 receptors antagonist), on feeding behavior in neonatal layer-type chickens fedad libitum
Material and In experiment 1, birds ICV injected with control solution and 2-AG (0.25, 0.5 and 1 μg). In experiment 2: control solution, SR141716A (6.25, 12.5 and 25 μg) were ICV injected to birds. In experiment 3 animals received: control solution, SR141716A (6.25 μg), 2- AG (1 μg) and co-injection of SR141716AAG. Then, cumulative food intake was recorded until 120 min after injection.
According to the results, 2-AG dose dependently increased cumulative food intake while SR141716A reduced appetite compared to control group (P
These results suggest CB1 receptors have an important role on ingestive behavior in neonatal layer-type chicken fedad libitum and nutritional status (food deprived or satisfied) had no effect on food intake induced by CB1 receptors in chicken.