The Effect of Aerobic Training on Metabolic Parameters and Serum Level of Sirtuin1 in Women with Type 2 Diabetes

Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on sirtuin-1 level and cardiometabolic parameters in women with type 2 diabetes.
In this semi-experimental study with pretest – posttest design, twenty diabetic women (aged 43.92±5.2 y) were randomly assigned to aerobic training or non-exercising control groups. Aerobic training program was performed 50-60 min/d, 3d/wk, for 2 months. Serum levels of sirtuin-1, body composition and metabolic parameters were assessed before and after the training period. Data were analyzed by paired T test.
Adiposity indices, total cholesterol, triglyceride, LDL- cholesterol,blood glucose and insulin resistance index were significantly reduced in the intervention group compared to the control (p These findings show that aerobic exercise is associated with an improvement in siruin-1 levels and metabolic indices in women with type 2 diabetes.