Protective Effect of Galega officinalis Extract on Streptozotocin-Induced Kidney Damage and Biochemical Factor in Diabetic Rats

Diabetes mellitus (DM) is impairing secretion of insulin or resistance to insulin. Herbal medicine plays an important role in the management of DM. We aimed to test antidiabetic effects of Galega officinalis on diabetic rats.
Twenty-eight male Wistar rats were randomly divided into 4 groups (n=7). Diabetes was induced by streptozotocin (STZ) (50 mg/kg). Diabetic rats were calcified into a diabetic control group (DC), DHEG group (50 mg/kg hydroalcoholic extract of G. officinalis), DG group (5 mg/kg glibenclamide). After 20 days, rats" blood samples, kidney, liver, and pancreas were kept in -70°C to test blood levels of glucose, insulin, lipid profile, some oxidative stress markers and antioxidant enzymes.
The fasting blood sugar (FBS) levels in the normal, DHEG, and DG groups were significantly lower than the DC group (P The results of the present study indicated that G. officinalis could be beneficial for the treatment of diabetes through improving tissue sensitivity to insulin and preventing tissue damages.