The effect of a period rhythmic aerobic exercise with ginger consumption on serum levels of TNF-α and IL-6 and Insulin Resistance obese middle-aged women with diabetes mellitus

Diabetes is a metabolic disorder associated with neuropathy, renal diseases, peripheral vascular disease, atherosclerosis, high blood pressure and inflammation. The use of supplements, herbal extracts, and exercise training for the treatment of diseases and metabolic disorders has increased among people. Thus, the aim of this study was the study of The effect of a period rhythmic aerobic exercise with ginger consumption on serum levels of TNF-α and IL-6 and insulin resistance in obese middle-aged women with diabetes mellitus.
In this research study, 46 obese diabetic women (BMI > 30, blood fasting sugar more than 150-250 mg/dL, 45-60 years old) were selected and randomly assigned into four groups, ginger (n=12), aerobic exercise training ginger (n=12), aerobic exercise training (n=12) and control (n=10). Participants in supplementary groups received Four 250 mg capsules ginger extract 1000 mg daily for 10 weeks. Aerobic training program included 10 weeks of training, 3 sessions per week and each session was 60 minutes at 55% maximum heart rate during the first week and gradually increased with the progress of the training program to 75 percent of maximum heart rate. Each session consists of warm up (10 minutes), the main part of the training involves performing aerobic exercises in a standing position (40 minutes) and recovery in sitting (10 minutes).
The data showed in training Ginger group, significant difference in serum TNF-α (p=0.028), IL-6 level (p=0.012), Insulin resistance (p=0.009), insulin (p=0.007) and fasting glucose (p=0.000) The results of analysis of variance showed that a no significant difference between the effects of different interventions do not exist for TNF-α(P=0.324) and IL-6(P=0.084) But there are between insulin resistance (p=0.001), insulin (p=0.007) and fasting glucose (p=0.001).
According to obtained results, it appears that aerobic training plus ginger extract consumption have better effect on serum inflammatory factors in obsess women with diabetes type 2.