Modeling the Effects of Biomechanical Factors on the Deformability of Metastatic Cancer Cells

The cancer changes the cytoskeleton of the cells .This change has some effects on the cell mechanobiology and will lead to some changes in the deformability of the cells. The moving ability of the cancer cells would be more than healthy cells. Thus, they can migrate through the tissue in human body. In this survey, a valid FEM of a cancer cell is presented. Then the effects of various factors such as membrane thickness, elasticity, strain, and frequency response are studied during a process of being converted from normal cells into cancerous malignant cells. Besides, the initial mathematical models are provided. The results clarify that an increase in membrane elasticity, strain, and frequency would lead to increase in the reaction force. However, an increase in the membrane thickness decreases the reaction force.