Decreased fibrinolytic activity is associated with carotid artery stiffening in arterial hypertension
Author(s):
Abstract:
Background
A prothrombotic state is associated with the presence and severity of organ damage in hypertensive patients. In these patients, evidence of subclinical carotid functional changes anticipates major cardiovascular events. The aim of this study was to investigate the association of hemostatic markers with carotid artery stiffness in hypertension.Materials And Methods
In 116 untreated essential hypertensive patients recruited at a referral center in the University of Udine, we assessed common carotid artery stiffness by B?mode ultrasonography and measured plasma fibrinogen, D?dimer, plasminogen activator inhibitor?1 (PAI?1), andhomocysteine by the currently available methods. For statistical reasons, the patients were divided according to the median value of each index of carotid stiffness, and continuous variables were further analyzed by univariate correlation and stepwise multivariate regression analysis.Results
PAI?1 levels were significantly higher in patients with low coefficient of distensibility (P = 0.018) and high Youngs elastic modulus (P = 0.012), whereas no association of fibrinogen, D?dimer, and homocysteine levels was observed with carotid coefficient of distensibility, Youngs elastic modulus, and ??stiffness. On univariate analysis, Youngs elastic modulus was significantly and positively correlated with PAI?1 levels (r = 0.286, P = 0.002), a correlation that on multivariate regression resulted to be independent of other confounders (? = 0.289, P = 0.028).Conclusion
An independent association of plasma PAI?1 levels with carotid artery stiffness suggests a possible contribution of decreased fibrinolytic activity to the early functional abnormalities of arterial vessels in hypertensive patients. This contribution might be relevant for subsequent development of hypertension?related cardiovascular complications.Keywords:
Language:
English
Published:
Journal of Research in Medical Sciences, Volume:22 Issue: 5, 2017 May
Page:
8
magiran.com/p1730745
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!