Association of Rubella, Cytomegalovirus, and Toxoplasma Infections with Recurrent Miscarriages in Bonab-Iran: A Case-Control Study

Recurrent miscarriage is defined as a condition with two or more consecutive abortions before the 20 weeks of gestation. Recurrent miscarriage is a multi-factorial disease, which occurs in approximately 1% - 2% of women at the reproductive age. Congenital infection is one of the most important factors in the recurrent miscarriages.
The aim of this study was to investigate the effects of rubella, cytomegalovirus, and toxoplasma infections on recurrent miscarriage in Bonab county.
This is a case-control study. Blood samples from a total of 100 women with recurrent miscarriage and 100 healthy women aged 20 to 35 years were taken and serum were separated. Antibodies against Rubella, Cytomegalovirus, and Toxoplasma were read by direct enzyme-linked immunosorbent assay (ELISA). Finally, data were statistically analyzed.
A total of 31 patients and 14 controls were positive for IgG antibodies against Toxoplasma. In addition, 27 persons in the patient group and 11 in the control group were positive for the presence of IgG antibodies against Cytomegalovirus. A total of 29 patients and 11 controls were positive for IgG antibodies against Rubella.
In this study, there was a significant difference in the prevalence of anti-Rubella, Cytomegalovirus, and Toxoplasma antibodies between women with recurrent miscarriage and healthy women.