Comparative efficacy of new antibacterial compounds against yersinia enterocolitica

Backgrond:Yersinia enterocolitica is zoonotic pathogen and one of important gastroenteritis agents. Some drug-resistant strains of this bacterium were discovered in the world. The use of new antibacterial compounds is one the best ways to deal with it. In this study, inhibitory effects of magnesium oxide nanoparticles, some heterocycles including thiazole, imidazolidine and tetrahydropyrimidine derivatives, poly-L-lysine and glycine were assessed against standard strains of Y. enterocolitica.
In this experiential laboratory study, antibacterial effect of all compounds were evaluated via the disk diffusion and broth microdilution methods. The results were reported as inhibition zone diameter (IZD), the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values. data were analyzed with the computer software SPSS version 19.0 (SPSS Inc., Chicago, USA), t.test and ANOVA.
Findings: No inhibitory activity against Y. enterocolitica were observed by MgO nanoparticles, poly-L-lysine and glycine. Thiazole derivative 7c was the only effective antibacterial agent on this bacteria with inhibition zone diameter 6.3±0.1, MIC 512 and MBC 1024 µg/ml with P- value It seams with antibacterial effects of compound 7c against standard strains of Y. enterocolitica, inhibitory activities of this compound against antibiotic-resistant strains of Y. enterocolitica as well as its toxic and therapeutic effects on laboratory animals are investigated in further research, thiazole 7c can be introduced as a new antibacterial agent.