The effects of berberis vulgaris juice on insulin indices in women with benign breast disease: a randomized controlled trial
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
BACKGROUND/
SUBJECTS/
Objectives
The aim of this study was to investigate the effect of Berberis vulgaris (BV) juice consumption on insulin homeostasis, glycemic profiles of patients with benign breast disease (BBD).SUBJECTS/
Methods
This parallel design, triple-blind, randomized and placebo controlled clinical trial was conducted on 85 eligible women diagnosed with BBD who recruited from Nour-Nejat hospital, Tabriz, Iran. Participants were randomly allocated into either intervention group who received BV juice (480 ml/day, n=44) or BV juice placebo group at the same time (480 ml/day, n=41). After a 7 day run-in period, treatments were administered for the duration of 8 weeks. Participants, care givers and those who assessed laboratory analyses were blinded to the assignments (IRCT registry no: IRCT2012110511335N2).Results
The relative treatment effects of BV supplementation showed decreased serum levels of insulin for 19%, C-peptide for 8%, homeostasis model assessment of insulin resistance index (HOMA-IR) for 16% and glucose to insulin ratio for 22% but HOMA-B increased 44% relative to placebo group over 8 weeks BV supplementation. Although these changes were not statistical significant, the mean changes for C-peptide and HOMA-B were significant just after adjusting for baseline data and covariates.Conclusions
Administration of BV juice showed controlling effects on HOMA related indices, consequently might have beneficial effects on insulin signaling-related functions in women with benign breast tumor.Keywords:
Language:
English
Published:
Iranian Journal of Pharmaceutical Research, Volume:17 Issue: 1, Winter 2018
Pages:
110 to 121
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