The effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Objectives
The frst cause of tooth loss in developed countries is periodontitis and mostly occurs in people over 40 years old.Atorvastatinis a statin drug class, which has a revolutionary impact on the treatment of high cholesterol and also stimulates bone morphogenic protein which has osteogenic potential. The aim of this study was to evaluate the effect of local and systemic Atorvastatin in the treatment of periodontitis.Materials And Methods
Forty eight Sprague Dawley rats were randomly divided into six groups of eight in each; experimental periodontitis was induced by ligature in fve of them in each group daily (1) systemic Atorvastatin 12.5 mg/kg (2) systemic solvent (3) local Atorvastatin 0.25 mg/kg (4) local solvent (5) no drug was administered and group (6) left non-ligated, and rats were sacrifced on 11th day. Histopathological analysis on periodontal tissue; malondialdehyde (MDA) and superoxide dismutase (SOD) tests on serum were performed to investigate bone loss and inflammation. The statistical tests for MDA and SOD samples were one-way ANOVA with Duncan post-hoc whereas in histopathological samples nonparametric KruskalWallis and MannWhitney tests were used.Results
Although local injection and oral administration of Atorvastatin signifcantly decreased alveolar bone loss and serum MDA levels, no signifcant difference in their effectiveness was observed. Serum SOD levels were not signifcantly changed in all administered groups.P-value Conclusion
In this study, both local injection and oral forms of Atorvastatin decreased inflammation and bone loss in periodontitis. However, no signifcant difference in their effectiveness was detected. However, local injection is superior to oral form due to effective lower dose. Keywords:
Language:
English
Published:
Journal of Dental School, Volume:35 Issue: 4, Fall 2017
Page:
4
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