An Investigation of Anti-Inflammatory and Analgesic Effects of Short-Term Oral Consumption of Indomethacin on Improving Biochemical, Morphological and Functional Symptoms of DOMS

The aim of this study was to investigate the effects of oral administration of indomethacin on improving delayed onset muscle soreness) DOMS(. 20 healthy men were divided into two equal groups: experimental and control. The experimental group received 3 capsules of indomethacin (each capsule 25 mg) and control group received placebo daily. Before and 1, 24, 48 and 72 hours after the exercise protocol, the variables were measured. After the consumption of indomethacin or placebo capsules for 3 days, the exercise protocol was performed with 85% 1RM in four sets and every set until exhaustion. The analysis of variance with repeated measures was used to analyze the results. The results showed a significant reduction in CK and LDH enzyme concentration and pain and inflammation in the indomethacin group compared with the control group. Maximal isotonic force showed lower and significant reduction in the experimental group than the control group. Knee range of motion in the indomethacin group had less inflammation than the control group. It can be said that the consumption of indomethacin during recovery has beneficial effects on improving DOMS.