Head & Neck Interdigitating Dendritic Cell Sarcoma: A Case Report & Literature Review
Author(s):
Article Type:
Case Report (دارای رتبه معتبر)
Abstract:
Interdigitating dendritic cells (IDCs) act as antigen-presenting cells (APC) of the immune system and have the ability to stimulate T cells. These cells are mostly seen in the paracortex of the lymph node. The interdigitating dendritic cell sarcoma (IDCS) originating from the IDC is an extremely rare tumor. This tumor is observed in both lymph nodes and non-lymph nodes. This malignancy is difficult to diagnose due to its rarity, and thus far no guideline has been established for its treatment. However, it seems that the best treatment for this malignancy is radical resection of the tumor. Meanwhile, the role of chemotherapy and radiotherapy in the survival and recurrence of the tumor is not clear. In this study, we present a case of IDCS originating from a cervical lymph node, which was first exposed to mass resection, with IHC evaluation revealing negative CD1a, CD3, CD20, CD23, and CD21 factors and positive S100 and LCA factors. After confirming the diagnosis,modified radical neck dissection was performed. In the next stage, the patient underwent chemotherapy with an R-CHOP regimen (Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Oncovin, Prednisone) and neck radiotherapy. 18 months after the formation of the tumor, no sign of recurrence or metastasis was observed in the patient.
Keywords:
Language:
English
Published:
Basic and Clinical Cancer Research, Volume:10 Issue: 4, Autumn 2018
Pages:
40 to 46
magiran.com/p1920859
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!