Analgesic and anti-inflammatory activities of Zea mays leaves
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background & Aim
Zea mays leaf used traditionally in Ibibio ethno medicine in Southern Nigeria to treat malaria and other inflammatory diseases. These anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models.
Experimental
The effects of ethanol leaf extract of Zea mays (170 -510 mg/kg) on experimentally induced inflammation and pain were studied in rats using Carrageenin, egg albumin and xylene-induced inflammation as well as acetic acid-induced writhing and thermal induced pain models. The GCMS analysis of the most active fraction was carried out.
Results
The extract (170 -520 mg/kg) inhibited inflammation and pains caused by different phlogistic agents used in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001), though incomparable to that of the standard drugs used (ASA and indomethacin). The GC-MS revealed the present of polyunsaturated fatty acids and phenolic compounds which may be responsible for the observed activities of the extract.
Recommended applications/industries
The present study demonstrates that leaf extract of Zea mays might to be useful for the treatment of inflammation and pains.Keywords:
Language:
English
Published:
Journal of Medicinal Herbs, Volume:7 Issue: 2, Summer 2016
Pages:
73 to 82
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