The Association of miR-let 7b and miR-548 with PTEN in Prostate Cancer

This study aims to investigate the expression level of mir-let7b-3p and mir-548, which are involved in PTEN expression in tissue samples of prostate cancer patients versus benign prostate hyperplasia (BPH) and normal adjacent tissue. Prostate cancer tissues were obtained from patients after receiving informed consent. Total RNA extraction and cDNA synthesis were performed for determining gene expression. Ten patients were determined to have high Gleason scores (> 7), 36 and seven samples had intermediate Gleason scores (7?) and BPH, respectively, and 40 samples were derived from normal adjacent tissue. Downreg ulation of mir-let7b and upregulation of mir-548 expression significantly correlated with high-risk Gleason scores. The present study showed that miR-let7b and/or mir-548 can be considered as potential targets in prostate cancer therapy.