Effect of oral Allopurinol unilateral renal ischemia-reperfusion left anesthetized dogs

Re-establish blood flow to the kidney caused further damage to the kidney tissue.It seems that xanthine oxidase irreversibledecrease mitochondrial function and energy depletion.Activation of proteolytic enzymes are all factors which cause ischemia. The aim of this study Microscopic examination of oral allopurinol in renal failure and ischemia, a left-sided. In this study, 18 male dog native were selected and randomaly divided in to three groups (n=6). G1 : control.G2: Ischemic Reperfusion (n=6) . G3:IschemicReperfusion with oral administration of allopurinol (10 mg/kg)until 14days (n=6).For evaluation of renal ischemia-reperfusion a left-sideVentral-medialApproachwas used. Then samples for microscopic evaluation by ultrasonography-guided biopsy were evaluated.The results showed that increasing the thickness of Bowman's capsule, severe damage in epithelial cells, enlargement of the lumen and hyaline casts, cell necrosis and detachment basement membrane outer cortex and medulla, the presence of inflammatory cells in the interstitial hemorrhage and fibrosis are has it. According to the xanthine oxidase inhibitor allopurinol so as damage caused by ischemic reperfusion protective effect is not satisfactory(p≥0/05).