Royal jelly Accelerate healing of acetate induced gastric ulcer in male rats

Abstract Background

Scientific reports suggest that bee products are useful for healing of wounds.

The healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa were studied.Materials: 96 male Wistar rats divided into in 4 groups includes: Control (without treatment), Omeprazole (20 mg/kgw), and Royal jelly (50, 200 mg /kgw). Gastric ulcer was induced in all rats with100% acetic acid. Treatment groups received omeprazole or royal jelly from 1nd to 14th day after acetic ulceration.  The histopathological parameters were evaluated on 4, 7, 10,15th days after ulceration.

 The administration of royal jelly significantly reduced depth of gastric lesion (p<0.05) and attuned histopathological changes compere to control group. The largest healing effect of royal jelly was on the 10 day of treatment, and at its higher used concentration (200 mg/kg).  

These findings supported that royal jelly has valuable effects on Gastric ulcer healing, and can used for peptic ulcer therapy.