Effects of 12 weeks concurrent aerobic and resistance training on serum vaspin and C-reactive protein levels in obese middle-aged men

Vaspin is a new adipokine which is a member of serine protease inhibitor family and might improve insulin sensitivity. The aim of this study was to investigate the effect of concurrent training (aerobic and resistance) on vaspin, and C-reactive protein levels in middle-aged sedentary obese men.

20 sedentary obese men (age: 50.7 ± 2.1 years, the percent of body fat (BF): 31.10 ± 1.80, weight: 93.53 ± 5.22 kg, BMI: 30.88 ± 1.22 kg/m2) were selected and randomly divided into two groups. Training consisted of a combination of endurance training (10-34 minutes and intensity 50-75% of maximum heart rate) and resistance training (1-2 set with 10-12 repetitions and intensity of 50-75 percent one repetition maximum) for 12 weeks and three sessions per week with 48 hours' rest between sessions. Blood samples were gathered after 12 hours of fasting and 48 hours after the last training program.

Vaspin levels decreased significantly in the experimental group. The weight, BMI, and BF decreased 4.2%, 4.7, 7.6%, respectively,  and also insulin resistance decreased 7.1% in the exercise group than the control group. There was no significant relationship between vaspin changes and anthropometric indices, insulin resistance and C-reactive protein.

In conclusion, vaspin serum concentration is decreased in parallel with the decline in the weight, and insulin sensitivity following the combined aerobic and resistance exercise