An effective and efficient method for the synthesis of pyrazole-fused isocoumarins by the recyclable magnetic solid acid γ-Fe2O3-SO3H under solvent-free condition

A novel and effective method in order to improvement of synthesis of pyrazole-fused isocoumarins from available materials such as ninhydrin and arylhydrazones was consider in this paper. A variety of substituted pyrazole-fused isocoumarin were synthesized by a one-pot reaction of ninhydrin and arylhydrazone in ecxellent yields under solvent-free conditions. In this reactions γ-Fe2O3-SO3H was used as, reusable, green and efficient catalyst. The attractive advantages of this method are the high yields, mild condition and reusability of the catalyst. The pyrazole-fused isocoumarin derivatives have a wide range of biological activities such as antimicrobial, antimalarial, and some of them are known as GABA receptor.