Empirical study of Geometrical and Fluidic Parameters on Size of Droplets in Microfluidic Devices with Flow-Focusing Confinement

One of the most important challenges faced by pharmacists is the inability to produce drug carriers with precision and control in a specific number. Therefore, droplet production with the aid of microfluidic devices as adaptive devices with the wide range of application is used. The purpose of this research is producing droplets as a structure for drug carrier with the aid of microfluidic devices with flow-focusing geometry. Also, the effect of geometrical, mechanical and fluid characteristics on the diameter of the produced droplets (Using two types of oily paraffin and hexadecane separately as continuous fluid and water as a discrete fluid) has been evaluated, empirically. As a results, by increasing the angle between the main and secondary channels and increasing the width of the channels, the diameter of the droplets expanded exponentially and relatively linearly, respectively. However, by decreasing the viscosity ratio to the surface tension of the fluid, the diameter of the produced droplets decreases relatively linearly. Moreover, in all studies, when the regimen changes, the mutation of the microchip occurs, In addition, the flow rate of continuous phase increases and the diameter of the produced droplets decreases.