Clinical efficacy of Silybum marianum seed extract in treatment of type 2 diabetes mellitus and non-alcoholic fatty liver disease: a narrative review

Author(s):

Sayed Mohammad Mohammadi , Saeed Kianbakht , Shamsali Rezazadeh , Mojtaba Ziaee , Hasan Fallah Huseini*

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

Several clinical studies have been undertaken to investigate the potential therapeutic effects of Silybum marianum (S. marianum) seed extract (silymarin) in Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).

Objective

We performed the present narrative review to evaluate the efficacy of silymarin supplement for treatment of T2DM and NAFLD.

Methods

Electronic databases PubMed, Science Direct, Scopus, Google and Google Scholar were surveyed for the English and non-English human clinical trial papers published concerning the effects of silymarin on T2DM and NAFLD from January 2010 to April 2018.

Results

Sixteen articles regarding silymarin effects on T2DM and NAFLD in clinical studies have been included in this review. The anti-diabetic effect of silymarin was reported in four clinical trials in single formula and in one trial in combination with nettle and boswellia gum resin. The efficacy of silymarin or silybin has been reported in the treatment of NAFLD in eleven clinical trials as single formula or in combination with phosphatidylcholine, simvastatin and vitamin E.

Conclusion

Silymarin appears to be effective as an adjuvant with the standard therapy in the treatment of T2DM and NAFLD.

Keywords:

Clinical trial , Diabetes mellitus , Fatty liver , Silymarin

Language:
English
Published:
Journal of Medicinal Plants, Volume:18 Issue: 73, 2020
Pages:
12 to 26
https://magiran.com/p2129669  
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