BF3.SiO2 Nanoparticles: Efficient and Green Catalyst for the One-Pot Synthesis of pyrano[2,3-d]pyrimidine Derivatives

Silica- supported boron trifluoride nanoparticles (BF3. SiO2 NPs) was prepared and used as a mild green solid acid catalyst for the synthesis of pyrano[2,3-d]pyrimidine derivatives from the reaction of aromatic aldehydes with ethylcyanoacetate and barbituric acid in ethanol. The reaction was efficiently promoted by BF3. SiO2 NPs and the heterogeneous catalyst was recycled for three runs in this reaction without losing its catalytic activity. Reusable and eco-friendly catalyst, simple work up procedure, easy separation of product from reaction mixture, safe and clean reaction giving high yield of the corresponding pyrano[2,3-d] pyrimidine in a short time, are some advantages of this protocol.