Effects of Resveratrol on the Level of Urotensin II and its Receptors in the Homogenized Tissue of Diabetic Rats

Individuals with diabetes mellitus are at serious risk of a wide range of cardiovascular complications. Urotensin 2 and its receptors play an important role in the development of cardiovascular diseeases through production of reactive oxygen species (ROS). Resveratrol is a polyphenol with antioxidant and anti-diabetic properties. The present study aimed to investigate the effects of resveratrol on urotensin 2 and its receptors in the heart tissues of diabetic rats.

In this experimental study, 48 male Wistar rats were divided into six groups (N= 8 in each group). Resveratrol was prepared in 0.5% carboxymethyl cellulose and given to the rats through oral gavage. At the end of the 60 days of treatment with resveratrol, rats’ heart tissue was collected.

The weight of diabetic rats treated with 10 and 90 mg/kg bw of resveratrol significantly increased compared with the diabetic group. Furthermore, the serum levels of FBS, lipids, MDA, CK-MB and LDH decreased in the treated diabetic rats compared with the control group. Moreover, concentration of urotensin 2 and its receptors significantly decreased in the heart tissues of the diabetic rats treated with resveratrol at the dose of 10 mg/kg bw compared with the control group.

The current study indicated that resveratrol decreased FBS, lipids, weight, MDA and cardiac enzymes. Furthermore, resveratrol significantly reduced urotensin 2 and its receptors, which indicates its moderating effect on diabetes complications.