Synthesis of Pt-SWCNTS Conductive Nanocomposite by Microwave Heated Polyol Strategy; Application for Amplification of 5-Fluorouracil Anticancer Drug Electrochemical Sensor

In this study, a simple strategy was described for the synthesis of Pt-SWCNTs conductive nanocomposite by microwave heated polyol method and nanocomposite characterized by EDS, FESEM, and XRD method. The Pt nanoparticles were decorated at the surface of SWCNTs with a diameter of 22.3 nm. The synthesized nanocomposite was used for modification of the carbon paste electrode (CPE) in the presence of n-hexyl-3-methylimidazolium hexafluorophosphate (nH3MHP) and paraffin oil as binders. The Pt-SWCNTs/nH3MHP/CPE was showed a good catalytic effect for electro-oxidation of the 5-fluorouracil anticancer drug in aqueous solution. In comparison to CPE, the Pt-SWCNTs/nH3MHP/CPE increased oxidation current of 5-fluorouracil (⁓4.47 times) and reduce oxidation potential of this anticancer drug ⁓125 mV. On the other hand, Pt-SWCNTs/nH3MHP/CPE was successfully used for the determination of 5-fluorouracil anticancer drugs in injection samples with acceptable recovery data (96.13%-103.5%). According to recorded results, the sensor has a powerful tool for determination of 5-fluorouracil anticancer drug in real samples.