XRCC3 repair role and risk of breast cancer: review article

Breast cancer is the most frequent women cancer in worldwide. Biological and epidemiological data suggest that induced damage by endogenous and exogenous factors affects the integrity and stability of DNA; moreover, it is associated with susceptibility of breast cancer. The XRCC3 gene is one of the most important and repaired genes that, by producing the XRCC3 protein, play a significant role in repairing DNA double-strand breaks and repairing them by recombination method. In other words the product of XRCC3 gene plays a key role in homologous recombination repaired of DNA double-strand breaks and it presents breast cancer with its function. The aim of this study was to investigate the relationship between XRCC3 gene and breast cancer.                 

This review article has been performed by searching breast cancer, the XRCC3 gene, the double-stranded DNA repair, and the homologous recombination repair keywords in various data bases such as NCBI, PubMed, Scopus, Science Direct, and Google Scholar.

Changes including mutations, deletions, displacements, duplication, and singlenucleotide polymorphisms in DNA repair genes such as XRCC3 make a difference in the repair efficiency of DNA damage. Therefore, these damages can lead to breast cancer.                       
 Discussion and

Any change in the XRCC3 gene leads to disruption of the genome repair process; therefore, it plays an important role in the development, growth and progression of breast cancer. The XRCC3 gene can be used as a marker gene in personal medicine for the prevention and screening of breast cancer, as well as a therapeutic goal in the field of breast cancer.