Effect of elastic band resistance training on mir-217 expression and cardiovascular risk factors in menopausal obese elderly women

Unfavorable changes occur in the body composition and lipoprotein that are related to the loss of estrogen levels after menopause. The aim of this study was to investigate the effect of 12 weeks elastic band resistance training on mir-217 expression and cardiovascular risk factors in menopausal obese elderly women.

In this single blind randomized clinical trial (RCT), 49 elderly women with obesity (age 64.13 ± 3.68 years, fat percentage 45.4 ± 6.56 %, BMI 33. 1 ± 3.71 kg/m2) were divided into two groups: control (n=10) and training (n = 14). The training group performed elastic band resistance training for 12 weeks and three sessions per week for all major muscle groups. Forty eight hours before and after 12 weeks of intervention, a DEXA test was performed.

The results of the intergroup comparisons indicated a significant decrease in mir-217 expression and LDL levels and a significant increase in HDL in the training group compared to the control group (P≤0.05), whereas there was no significant difference in body weight, body mass index, fat percentage, total cholesterol and CRP (P≥0.05).

It seems that 12 weeks elastic band resistance training have been able to modulate and reduce the serum concentration of mir-217 in obese elderly women, which was associated with a decrease in LDL levels and increase levels of HDL. Although body mass index, fat percentage, total cholesterol and CRP Significant changes were not observed, which requires further investigation in this field.