Investigation of the effects of copper sulfate on sperm quality parameters, DNA fragmentation rate and testicular tissue of adult rats of wistar breed
Copper sulfate is one of the most important environmental pollutants that has the ability to produce free radicals and create oxidative stress. The aim of this study was to investigate the effects of copper sulfate on sperm quality parameters, DNA fragmentation rate and testicular tissue of adult Wistar rats.
In this experimental study, 30 adult Wistar rats weighing 250-200 grams were used. Random adult mice were treated in 3 control groups, copper sulfate receptor with concentration (100 mg / kg) and concentration (200 mg / kg) for 56 days. At the end of the treatment period, testicular weight, sperm count and parameters were assessed based on (WHO2010). The quality of sperm chromatin was assessed by acridine uranium nuclear pigments. Malondialdehyde level was measured. Data were analyzed using the One-Way ANOVA statistical method.
The quality of sperm parameters in copper sulfate with a concentration of 200 mg / kg decreased significantly (P <0.05). The testicular weight was significantly reduced at a dose of 200 mg / kg (P <0.05). The diameter of the seminiferous tubules, testosterone levels,, germ cell count, and sperm DNA fragmentation rate decreased at a dose of 200 mg / kg (P <0.05). The concentration of malondialdehyde at a dose of 200 mg / kg sulfate copper was significantly increased (P <0.05).
This study shows that high concentrations of copper sulfate cause destructive effects on sperm quality, testicular tissue.
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