Dynamic modeling of hyperthermia treatment with simultaneous solving of convection-diffusion in tumor tissue

In the treatment of magnetic hyperthermia (MFH), tumor cells are degraded under the heat generated by magnetic nanoparticles (MNPs) under an intermittent magnetic field. The function of MFH treatment depends on factors such as concentrations and the distribution of MNPs within the tumor's interstitial space. A prominent method for the accumulation of MNPs within the tumor area is arterial infusion. In this study, a complex numerical model based on the solution of advanced mathematical equations, by injection of MNPs into the arteries, the transfer of a soluble substance from the wall to the arteries through the presence of a concentration gradient due to the difference in plasma concentration and interfacial concentration leads to the diffusion mechanism , And fluid movement due to the pressure gradient leads to the displacement of MNPs. For this purpose, in three constant concentrations of plasma, 130 mol/m^3 , 150mol/m^3 , 170mol/m^3 0, based on two continuous injections and mass injections, their effects on the concentration of the antifungal fluid and The temperature field is treated during hyperthermia magnetic therapy.