The Effect of Aerobic Training on Parathyroid Hormone and Alkaline Phosphatase as Bone Markers in Men with Mild to Moderate Asthma

Inhalation of corticosteroids in patients with asthma is associated with an increased risk of osteoporosis. This study aimed to assess the effect of aerobic training on alkaline phosphatase(ALP), parathyroid hormone (PTH) as bone biomarkers in men with mild to moderate asthma.

Twenty four sedentary middle-aged men with asthma aged 40±5 years were randomly assigned to two groups as exercise (aerobic training, n=12) and control (no training, n =12). Aerobic training was performed 3 days a week for 12 weeksin the form of running on a flat surfaceat 60-75% of HRmax. Fasting blood samples were taken before and after the training program for measuring serum ALP and PTH.

There were no statistically significant differences between groups with regard to anthropometrical and bone markers at baseline (p>0.05). Aerobic training resulted in significant increase in ALP (p= 0.023) and PTH (p= 0.016) in exercise individuals. All variables remained unchanged in the control group(p>0.05).

With an emphasis on the increase in ALP and PTH, it is concluded that relatively long-term aerobic exercise is associated with improved bone formation markers in patients with asthma treated with inhaled corticosteroids.