The Evaluation of Serum Lipids and Oxidative Stress Indices Following Propofol Administration in Broilers

The oxidative stress is one of the side effects of anesthesia. This study aimed to evaluate the changes in oxidative stress indices following propofol administration in broilers. For this purpose, 90 Ross broiler chicks were divided into two main and control groups. Anesthesia was induced by the injection of 2 mg propofol per kg of bird weight, intra-bone injection to induce anesthesia, and 0.5 mg propofol per kg bird weight to continuous anesthesia. To evaluate the serum lipids and oxidative stress indices (catalase activity, malondialdehyde concentration, and total antioxidant capacity), blood sampling was performed before anesthesia, during anesthesia, and 24 hours after the anesthesia. The results showed that the activity of serum catalase in 24 h after anesthesia (129.5 ± 6.69) was significantly higher than control chickens and its level during anesthesia (112.9 ±5.04), and before anesthesia (120.9 ± 4.21). The malondialdehyde concentration did not increase during anesthesia (34.3 ± 1.54), whereas it significantly increased 24 h after anesthesia (42.8 ± 4.28). Total antioxidant capacity significantly decreased 24 h after anesthesia (19.2 ± 1.67) compared to before (25.9 ± 1.27) and during anesthesia (27.4 ± 1.37). Total antioxidant capacity significantly increased before and during anesthesia compared to 24 h after anesthesia. Serum lipid indices did not change during the experiment. In general, this study's results showed that although using propofol in broiler chickens during anesthesia can effectively neutralize free radicals and prevent the side effects of oxidative stress, after anesthesia, oxidative stress indices increase.