Correlation between Serum Calcium and Cardiovascular Outcome among Patients Suffering From Acute Coronary Syndrome

There have been no studies investigating the association of serum calcium level upon admission with long-term cardiovascular outcome among patients suffering from acute coronary syndrome (ACS).

This study aimed to explore the correlation of serum calcium level upon admissionwith cardiovascular outcomesamong ACS patients.

This longitudinal study included 105 ACS or suspected ACS patients who were referred to the Coronary Care Unit fromJune 1st, 2015, to August 31st, 2016. Serum calcium was measured upon admission, and the patients were followed up until November 30th, 2016. Cardiovascular death or cardiovascular re-hospitalization was the study's end.

According to the median of serum calcium, the patients were divided into two groups of lower (n=47) and higherserum calciumlevel (n=58). The results of the Kaplan-Meier analysis revealed thatpatients with lower serum calcium obtained a significant decrease in cardiovascular event-free survival (log-rank χ2=5.594, P=0.018), compared to those with higher serum calcium level. Furthermore, lower serum calcium level (HR=0.265, 95% CI=0.072-0.981, P=0.047) independently correlated with poor cardiovascular outcome in ACS or suspected ACS patients after adjusting the potential confounders in the multivariable Cox model.

Lower serum calcium level upon admission independentlycorrelated withpoor long-term cardiovascular outcomes in patientswithsevere coronary artery disease.