Salivary evaluation of p53 and MMP-3 in patient with oral lichen planus

Lichen planus is an inflammatory chronic illness with unknown cause that can irritate the oral mucosa. P53 is associated with malignant changes in oral epithelial cells. MMPs can destroy intercellular junctions and cause acantholysis. It seems that MMP-3 plays a significant role in this regard. The purpose of this study was to evaluate the salivary levels of P53 and MMP-3 in the patients with Oral Lichen planus (OLP) compared with the control group.

30 salivary samples were collected from patients with OLP (15 with erosive Oral Lichen planus (EOLP) and 15 with reticular Oral Lichen planus (ROLP)) and 30 salivary samples from healthy people as a control group. The salivary P53 and MMP-3 level was assayed by ELISA method. Statistical analysis of the Student’s t-test, ANOVA and Pearson correlation coefficient was performed.

The salivary concentrations of P53 and MMP-3 in patients with EOLP were significantly higher than patients with ROLP and control group, but no significant difference was found between control group and patients with ROLP.

The salivary concentrations of P53 and MMP-3 were significantly different between different clinical types of OLP.