One-pot three-component synthesis of hydroquinazolinone derivatives using silicotungstic acid under solvent-free conditions

Author(s):

Asadollah Hassankhani * , Esmaeil Sanchuli

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:

 In this research paper, a simple, efficient and green procedure was reported for the one pot preparation of 2,3-dihydroquinazoline-4(1H)-one derivatives using silicotungstic acid as catalyst. Hydroquinazolinone derivatives can obtained from condensation of isatoic anhydride, aromatic aldehydes and ammonium acetate in good yields. The reaction completed at 100 oC within 10-15 min with yields of 88-94%. Shorter reaction times and higher yields were chieved under under solvent-free conditions.

Keywords:

Hydroquinazolinones , Multicomponent reaction , Solvent-free conditions , Ttungstosilicic acid

Language:
Persian
Published:
Journal of Chemical Research, Volume:1 Issue: 1, 2019
Pages:
32 to 38
https://magiran.com/p2259684