Incidence Of Acute Kidney Injury Due To Contrast Usage In Patients Admitted To Mofid Children Hospital (2019-2020)

Contrast-induced renal impairment endangers patients' health and imposes a financial burden on families and the health care system. Therefore, this study examines the rate of nephropathy in patients admitted to the Mofid Children's Hospital in 2018 and 2019.

This study was a retrospective cross-sectional study in a useful pediatric hospital on 180 children in which contrast-enhanced CT-scans were performed. Baseline serum creatinine and then serum creatinine were determined 48-72 hours after CT-scan and in case of more than 25% increase in serum creatinine, it was considered CIN. Shapiro-Wilk test was used to check the normality of quantitative data distribution. Independent t-test, Mann-Whitney and Chi-square (if necessary Fisher's exact test) were used to compare the characteristics between the two groups of patients. The research data were analyzed using SPSS-25 software and the significance level in all tests was considered to be P <0.05.

In this study, 180 children who underwent contrast-enhanced CT-scan with a mean age of 5.72 years, of which 81 (45 ٪) were girls and 99 (55 ٪) were boys. The mean baseline creatinine of patients was 0.633 ± 0.137 mg / dl and the mean creatinine of patients two weeks after the first measurement was 0.675. 0.164 mg / dl. Patients' creatinine levels increased statistically significantly after two weeks.

In children on CT scan with an increase in contrast, the incidence of ARF is 17.2%. Ciprofloxacin increases the risk of acute kidney problems by 4.8 times.