Association between Serum IL-4 Levels and Cyst Relapsing in Cystic Echinococcosis

IFN-y and IL-4 levels of peripheral blood mononuclear ccli (PBMC) cultures and sera of Ihe cyslic echinococcosis palienls wilh primary and relapsed infeclions were compared. In Ihis regard. PB MC of Ihe patienls and controls were eullured in RPMI and stimulaled wilh different hydatid Iluid antigens of (SHf. pI-l5PPT, B-Ag, FI and F2). IFN-y and IL-4 of the culture supernatanls as weil as the sera of echinoeoecosis palienls wen: evaluated by ELISA. The results indicale thal the level of IL-4 produced by PBMC of the patients was higher Ihan thal of heallh)' group and the diffen::ncc was signifieant. The levels of IL-4 in PBMC eullure and sera of Ihe palienls with relapsed hydatidosis were significantly higher th an Ihose wilh primary infection means the immune response paltern of the patients. who have nol receiwd any anliparasitic drug aller surgery. ma)' shift loward Th2 activalion and suseeplibilily 10 Ihe infeclion. Contrar)'. the levels of IFN-y produccd bl' PBMC and in sera of Ihe palients Ircaled surgicall) once do not di/Ter significantly with Ihose tn:ated two limes or more.