What is the High-Throughput Screening (HTS) tes t method?
High-throughput experimentation (HTE) or High-throughput screening (HTS) is revolutionary method in the pharmaceutical, biological and chemical indus tries, especially in the field of pharmacy, has enabled the rapid screening of large-volume hybrid libraries for various therapeutic research purposes. The pas t decade has also witnessed the extension of HTS principles toward field of chemis try and catalys ts. Today, mos t major pharmaceutical, biological and chemical companies have created dedicated HTE Sys tems. In the second part of the article, an example of the implementation method, challenges and application of this technique in the field of chemical research will be introduced. Illustrative examples have been carefully chosen to inspire, rather than prescribe, how HTE can be used to solve complex problems in synthesis. Furthermore, the intent is to present HTE not jus t as a tool for expert users in highly automated laboratories, but as an enabling approach to reaction discovery, development, and optimization that can be broadly employed by all chemis ts conducting research.
HTS , HTE , High-Throughput Experimentation , Chemis try , Catalys ts , HPLC , UPLC , Array , Solvents , Ligands
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